The roles of ARID1A in gynecologic cancer

 open access




 Received Aug 6, 2013, Accepted Aug 7, 2013
This article was solicited and has not been peer reviewed

CONCLUSION
Disorganized chromatin structure is known to be associated
with the appearance of various abnormal phenotypes,
including cancer [53,54]. ARID1A , a gene participated in
chromatin remodeling, is an emerging tumor suppressor
gene. Accumulating evidence has reported somatic inactivating
mutations of ARID1A and loss of its expression in many
types of human cancers, especially in endometrium-derived
tumors, including ovarian clear cell carcinomas, ovarian endometrioid
carcinomas and uterine endometrioid carcinomas.
The high prevalence of somatic mutations in those ovarian
and endometrial cancers indicates a pivotal role of ARID1A in
their development. Understanding the roles of ARID1A in the
pathogenesis of endometrium-derived tumors is fundamental
for future translational studies aimed at designing new
diagnostic tests for early detection and identifying critical
molecular targets for new therapeutic interventions.