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open access
Article Outline
- Abstract
- Pulmonary
- Genitourinary
- Musculoskeletal
- Gastrointestinal
- Monitoring for Recurrence
- Conclusions
- References
•Organ,
tissue, or systemic damage related to therapy. Typically, this will
include local scarring and inflammation due to surgery or radiation
therapy. In addition, systemic therapy may cause inflammation, scarring,
or necrosis in a broad range of target organs, including the lung,
liver, kidneys, brain, and peripheral nerves.
•Emergence
of a new cancer site: This will most frequently represent
late-recurrence of the initial treated tumor. However, second primary
cancers may result from the same underlying germline mutation that
produces the original tumor (eg, ovarian cancer in BRCCA1 mutations) or
as a result of mutagenic effects of radiation or chemotherapy.
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