abstract
BACKGROUND:
This
study aimed to examine family history among Japanese ovarian cancer
patients and to investigate the TP53 status of fallopian tube epithelial
and ovarian cancer cells in a Japanese BRCA1 mutant case that may be
associated with the transformed state in hereditary ovarian cancer.
METHODS:
One
hundred and two primary ovarian cancer patients were retrospectively
evaluated in this cross-sectional study. The family history of cancer
was determined in probands. In a BRCA1 mutant case, p53 immunostaining
and direct sequencing, followed by laser-capture microdissection, were
performed for the fallopian tube, considered the origin of ovarian
cancer.
RESULTS:
Nine of 102 (8.8%) families were
regarded as having hereditary breast-ovarian cancer syndrome, two
families (2.0%) were diagnosed with Lynch syndrome and six patients
harbored BRCA1 or BRCA2 mutations. One case underwent risk-reductive
salpingo-oophorectomy as a BRCA1 mutant carrier was retrospectively
diagnosed as occult cancer. Common TP53 mutations were detected in
cancer and fallopian tube epithelial cells in the case.
CONCLUSIONS:
Here,
we integrate family cancer history and histology in ovarian cancer
cases as well as TP53 status in a BRCA1 mutant case into a discussion
regarding carcinogenesis in a Japanese population. The TP53 status for
the BRCA1 mutant case examined here supports the recently proposed
theory that ovarian cancer develops because of BRCA1 or BRCA2
inactivation and/or TP53 mutations.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.