Monoclonal antibody-based immunotherapy of ovarian cancer: targeting ovarian cancer cells with the B7-H3-specific mAb 376.96

abstract

Highlights

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The mAb 376.96 defined B7-H3 epitope is expressed by chemosensitive and chemoresistant ovarian cancer cells, as well as patient tumors

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mAb 376.96 enhanced the cytotoxicity of Sunitinib in vitro

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Further studies are warranted examining B7-H3 as a potential target of mAb-based immunotherapy in ovarian cancer