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abstract
We
have conducted a retrospective analysis of FIGO stage 1 ovarian cancer
patients in South Wales, who underwent a simplified staging laparotomy
without routine nodal sampling and peritoneal biopsies. Patient records
from January 2004 to December 2010 were analysed. A total of 116
patients were included in the final analysis. Adjuvant chemotherapy was
offered to patients with risk factors for relapse (grade > 1, clear
cell histology, or stage > Ia); overall, 89 patients (76.7%) received
adjuvant single agent carboplatin (n = 54, 46.5%) or combination
chemotherapy (n = 35, 30.2%). After a median follow up of 41 months
(range 12-95), 18 patients have relapsed (15.5%), of these 17 had risk
factors and 16 had received adjuvant chemotherapy. Eighteen patients
have died, of whom 6 of non-cancer related causes without prior relapse.
5-year overall and relapse free survival were 80%.
In conclusion, in situations where there are limited resources and operating time constraints, our data suggest that a simplified staging laparotomy approach may be a reasonable compromise in apparently early stage ovarian cancer: this may result in a more aggressive use of chemotherapy, but survival outcomes seem comparable to other series.
In conclusion, in situations where there are limited resources and operating time constraints, our data suggest that a simplified staging laparotomy approach may be a reasonable compromise in apparently early stage ovarian cancer: this may result in a more aggressive use of chemotherapy, but survival outcomes seem comparable to other series.
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