(BRCAPRO) Misreported Family Histories and Underestimation of Risk

open access

To the Editor:

The study by Daniels et al¹ focused on women with high-grade serous ovarian cancer and showed that carrier probabilities provided by risk prediction model BRCAPRO² are too low among low-risk patients. This important observation agrees with earlier reports, including probands with both ovarian and breast cancers,² in which the ratio of observed to expected cases (O/E) in low-risk groups was substantially greater than one. As genetic testing becomes more affordable and appropriately broadens to segments of the population who are at lower prior risk, this limitation deserves serious consideration........