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open access
Cancer Causes Control
Results
Current
cigarette smoking increased the risk of invasive mucinous (OR = 1.31;
95 % CI: 1.03–1.65) and borderline mucinous ovarian tumors (OR = 1.83;
95 % CI: 1.39–2.41), while former smoking increased the risk of
borderline serous ovarian tumors (OR = 1.30; 95 % CI: 1.12–1.50). For
these histological types, consistent dose– response associations were
observed. No convincing associations between smoking and risk of
invasive serous and endometrioid ovarian cancer were observed, while our
results provided some evidence of a decreased risk of invasive clear
cell ovarian cancer.
Conclusions
Our
results revealed marked differences in the risk profiles of
histological types of ovarian cancer with regard to cigarette smoking,
although the magnitude of the observed associations was modest. Our
findings, which may reflect different etiologies of the histological
types, add to the fact that ovarian cancer is a heterogeneous disease.
"....In conclusion, in this large pooled analysis, we observed moderate increases in risk of invasive and borderline mucinous tumors and borderline serous tumors associated with cigarette smoking. For each of these histological types, the risk increased with increased daily cigarette consumption and duration of smoking. This dose–response relationship supports a causal association between smoking and ovarian cancer. In contrast, our results suggest that smoking is not likely to importantly increase the risk of invasive serous ovarian cancer. There was a decreased risk of invasive clear cell ovarian cancer in relation to smoking. Thus, our results indicate that differences in risk profiles with regard to cigarette smoking are not only present between mucinous and non-mucinous ovarian tumors but across the major histological types of invasive ovarian cancer. These findings further underscore the importance of histological subtype analyses in epidemiological, genetic, and clinical investigations of ovarian cancer, due to the vast heterogeneity in this disease."
"....In conclusion, in this large pooled analysis, we observed moderate increases in risk of invasive and borderline mucinous tumors and borderline serous tumors associated with cigarette smoking. For each of these histological types, the risk increased with increased daily cigarette consumption and duration of smoking. This dose–response relationship supports a causal association between smoking and ovarian cancer. In contrast, our results suggest that smoking is not likely to importantly increase the risk of invasive serous ovarian cancer. There was a decreased risk of invasive clear cell ovarian cancer in relation to smoking. Thus, our results indicate that differences in risk profiles with regard to cigarette smoking are not only present between mucinous and non-mucinous ovarian tumors but across the major histological types of invasive ovarian cancer. These findings further underscore the importance of histological subtype analyses in epidemiological, genetic, and clinical investigations of ovarian cancer, due to the vast heterogeneity in this disease."
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