Oncolytic measles virus expressing the sodium iodide symporter to treat drug-resistant ovarian cancer

abstract


Edmonston vaccine strains of measles virus (MV) have significant antitumor activity in mouse xenograft models of ovarian cancer (OvCa). MV engineered to express the sodium iodide symporter gene (MV-NIS) facilitates localization of viral gene expression and offers a tool for tumor radiovirotherapy......

.....Here we report results from a clinical evaluation of MV-NIS delivery in patients with taxol and platinum resistant OvCa. MV-NIS was given intraperitoneally every 4 wk for up to 6 cycles. ........... Our findings support further clinical evaluation of MV-NIS as an effective viral immunotherapy.