|
|
|
|
|
|
|
|
abstract
Background A
comprehensive body of evidence has shown that aspirin has
cancer-preventive effects, particularly against gastrointestinal
cancer, but its effects on the risk of ovarian
cancer are less well established. This nationwide case-control study
examined
the association between low-dose aspirin and the
risk of ovarian cancer.
Patients and methods
We identified all patients in the Danish Cancer Registry aged 30–84
years old with a histologically verified first diagnosis
of epithelial ovarian cancer during 2000–2011.
Each patient was sex- and age-matched to 15 population controls using
risk-set
sampling. Prescription use, comorbidity,
reproductive history and demographic characteristics data were obtained
from nationwide
registries. Use of low-dose (75–150 mg) aspirin
was defined according to dose and duration and consistency of use.
Conditional
logistic regression was used to calculate odds
ratios (ORs) with 95% confidence intervals (CIs) for the association
between
low-dose aspirin use and the risk of epithelial
ovarian cancer, both overall and for specific histological types.
Results For 4,103
ovarian cancer cases and 58,706 population controls, the adjusted OR for
epithelial ovarian cancer associated with
ever use (≥2 prescriptions) of low-dose aspirin
was 0.94 (95% CI: 0.85–1.05). ORs for epithelial ovarian cancer were
lower
with the use of 150 mg aspirin tablets (OR=0.82;
95% CI: 0.68–0.99) and with long-term use (≥5 years) of low-dose
aspirin
(OR=0.77; 95% CI: 0.55–1.08). Continuous
long-term use of low-dose aspirin, defined as close consecutive
prescriptions, was
associated with a further reduction in OR (0.56;
95% CI: 0.32–0.97). For histological types of epithelial ovarian
cancer,
the strongest inverse associations with low-dose
aspirin use were seen for mucinous and endometrioid tumours.
Conclusion This nationwide case-control study indicates that low-dose aspirin use may be associated with reduced risk of epithelial
ovarian cancer.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.