Cancer Epidemiol Biomarkers Prev. 2015 Apr 14
BACKGROUND:
Risk
factors for invasive epithelial ovarian cancer (IEOC) among Hispanics
and African Americans are under-studied despite notable differences in
incidence relative to non-Hispanic Whites.
METHODS:
We
used multivariate logistic regression to examine parity, oral
contraceptive use, tubal ligation, endometriosis, family history of
ovarian cancer, and talc use and risk of IEOC among Hispanics (308
cases, 380 controls), African Americans (128 cases, 143 controls) and
non-Hispanic Whites (1265 cases, 1868 controls) using four case-control
studies we conducted in Los Angeles County. We expressed each of these
factors in the form of increasing risk and calculated population
attributable risk percentage (PAR%) estimates for the six risk factors
separately and jointly in the three groups.
RESULTS:
The
risk associations with these six well-accepted factors were comparable
in the three groups. The significant racial/ethnic differences in the
prevalence of these factors and differences in their oophorectomy rates
explained 31% of the lower incidence in African Americans compared to
non-Hispanic Whites, but only 13% of the lower incidence in Hispanics.
The PAR%s ranged from 27.5% to 31.0% for no tubal ligation, 15.9% to
22.2% for not using oral contraceptives, and 12.2% to 15.1% for using
talc in the three groups.
CONCLUSIONS:
All
six risk factors are comparably important in the three groups.
Differences in the prevalence of these factors and their oophorectomy
rates explained approximately one-third of the difference in incidence
between African Americans and non-Hispanic Whites.
IMPACT:
Devising strategies to lessen the burden of IEOC will be applicable to all three racial/ethnic groups.
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