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Tuesday, April 14, 2015

BRCA2 variant aerodigestive cancer risk



The Lancet Oncology - abstract

 A rare BRCA2 genetic variant, known as rs11571833 (K3326X), is strongly associated with squamous-cell cancers of the upper aerodigestive tract (UADT), a new study reports. BRCA2 is involved in DNA repair, and previous evidence has suggested significant associations of this variant with cancers of the lung, oesophagus, and pancreas, and to a lesser degree, with breast cancer. This new study adds UADT cancers to the list of diseases affected by rs11571833.

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