To
correlate CA125 levels after platinum- and paclitaxel-based
chemotherapy with progression-free survival (PFS) and overall survival
(OS) in advanced ovarian carcinoma following primary cytoreduction.
MATERIALS AND METHODS:
The study was conducted on 247 patients.
RESULTS:
By
log-rank test, PFS and OS were related to performance status (PS), residual disease,
ascites and post-chemotherapy CA125 using 10.8
U/ml as cut-off . PFS was related to
post-chemotherapy CA125 assay (cut-off values of 7.1 U/ml, 18.5
U/ml and 35.0 U/ml. OS was related to FIGO
stage (p=0.02). On multivariate analysis, residual disease, ascites and
post-chemotherapy CA125 with any selected cut-off were independent
prognostic variables for PFS, whereas residual disease, PS and
post-chemotherapy CA125 (10.8 U/ml as cut-off) were independent
prognostic variables for OS.
CONCLUSION:
Post-operative CA125 using 10.8 U/ml as cut-off was an independent prognostic variable for both PFS and OS.
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