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abstract
We examined the serum
concentration of human epididymis protein (HE4) in patients with benign
gynecological diseases complicated with chronic renal deficiency and its
significance in the differential diagnosis of benign and malignant
gynecological diseases. Serum HE4 and cancer antigen 125 concentrations
were detected by chemiluminescence. Clinically or pathologically
confirmed gynecological diseases were grouped and retrospectively
analyzed, including 50 cases of gynecological benign diseases, 35 cases
of non-mucinous epithelial ovarian carcinoma, 36 cases of endometrial
adenocarcinoma, 15 cases of gynecological benign diseases patients
complicated with chronic renal deficiency, 15 cases of gynecological
diseases without chronic renal deficiency, and 30 normal controls. Serum
HE4 values in the ovarian cancer group, endometrial cancer group,
gynecological benign diseases with chronic renal deficiency group, and
chronic renal deficiency group were significantly increased compared
with the benign gynecological diseases and normal control groups,
showing a significant difference (P < 0.001). A comparison of 4
groups with high HE4 showed that the HE4 level in the 2 groups with
renal deficiency were higher than those in the ovarian cancer and
endometrial cancer groups, but the difference was not significant (P
> 0.05); there was no significant difference between 2 groups with
renal deficiency (P > 0.05). Serum concentration of HE4 was high in
patients with chronic renal deficiency, which should be distinguished
during differential diagnosis of gynecological benign and malignant
tumors in patients with chronic renal deficiency to avoid misdiagnosis.
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