Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer
Ovarian Cancer and Us
OVARIAN CANCER and US
Ovarian Cancer and Us
We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 in patients with pancreatic cancer.
A small but clinically
important proportion of pancreatic cancer is associated with mutations
in known predisposition genes. The heterogeneity of mutations identified
in this study shows the value of using a multiple-gene panel in
pancreatic cancer.
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