Patient experiences living with pancreatic cancer risk (eg. HBOC/Lynch Syndrome/PJS...)

open access (small study)

....Within the general population, an individual has approximately a 1.41 % lifetime risk for developing PancCa [4]. However, PancCa is now considered both a familial risk related cancer and a component of hereditary cancer predisposition syndromes [5]. Based on consensus agreement [6], individuals are considered at high risk for PancCa due to family history if two or more first degree relatives or any three or more relatives, including at least one first degree relative, have a diagnosis of PancCa. Additionally, individuals with Peutz- Jeghers Syndrome and those with p16, Hereditary Breast and Ovarian Cancer Syndrome (HBOC) or BRCA1/2, ATM, PALB2, or Lynch syndrome gene mutations and one or more first degree relatives with PancCa are also considered at risk [4–6] due to genetic factors.Individuals who meet these criteria have higher risk burden ranging from a lifetime risk of
3.6 to 40 % [5, 6]. Consequently individuals with elevated risk live with the awareness that if diagnosed with PancCa most will die......