PLOS ONE: open access
Method
This
hypothesis was tested within 2,150 HBOC families encompassing 96,325
individuals. Parameters included counts of breast/ovarian cancer, age at
diagnosis, male breast cancer and other cancer locations. As expected,
well-known clinical parameters discriminated between BRCA-mutated
families and others: young age at breast cancer, ovarian cancer,
pancreatic cancer and male breast cancer. The major fertility
differences concerned men in BRCA-mutated families: they had lower first
and mean age at paternity, and fewer remained childless. For women in
BRCA families, the miscarriage rate was lower. In a logistic regression
including clinical factors, the different miscarriage rate and men's
mean age at paternity remained significant.
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