Clear cell carcinomas of the gynecologic tract and thromboembolic events: what do we know so far?

open access (2014)

..... specific malignancies that have been found to increase the risk of thromboembolic events (including gliomas, renal, gastric and pancreatic carcinomas) [2,5,6]. In ovarian cancer patients......

...... The occurrence of thromboembolic events has been found to adversely impact survival in several reports, even in patients with localized disease [6–8]......

 The observation that cancer patients may have an increased risk for thromboembolic events was originally made by the French internist Armand Trousseau in 1865 [1]. Almost 150 years later, it is now well-recognized that cancer patients have a four- to seven-fold increase in their risk for venous thromboembolic events relative to their counterparts without cancer, and that 1–15% of cancer patients develop clinical thromboembolic events over the course of their care [2–4]. This increased risk has a multifactorial basis, the precise components of which are not entirely clear at the present time. However, in cancer patients, risk factors for increased thrombosis often abound, including the presence of medical comorbidities......