eg. SERPINA7 (clear cell) = thyroid
open access (technical)
Results
The
most significant evidence of an association for all invasive cancers
combined and for the serous subtype was observed for SNP rs17216603 in
the iron transporter gene
HEPH (invasive: OR = 0.85, P =
0.00026; serous: OR = 0.81, P = 0.00020); this SNP was also associated
with the borderline/low malignant potential (LMP) tumors (P = 0.021).
Other genes significantly associated with EOC histological subtypes
(p<0.05) included the
UGT1A (endometrioid),
SLC25A45 (mucinous),
SLC39A11 (low malignant potential), and
SERPINA7 (clear cell carcinoma). In addition, 1785 SNPs in six genes (
HEPH,
MGST1,
SERPINA,
SLC25A45,
SLC39A11 and
UGT1A)
were imputed from the 1000 Genomes Project and examined for association
with INV EOC in white-European subjects. The most significant imputed
SNP was rs117729793 in
SLC39A11 (per allele, OR = 2.55, 95% CI = 1.5-4.35, p = 5.66x10
-4).
Conclusion
These
results, generated on a large cohort of women, revealed associations
between inherited cellular transport gene variants and risk of EOC
histologic subtypes.
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