abstract (edited stats for ease of reading)
Epithelial Ovarian Cancer Metastatic to the Central Nervous System
and a Family History Concerning for Hereditary Breast and Ovarian
Cancer-A Potential Relationship.
OBJECTIVES:
To
estimate the frequency of hereditary breast and ovarian cancer (HBOC)
in women with central nervous system (CNS) metastasis from epithelial
ovarian cancer (EOC) and to evaluate for a potential relationship
between HBOC status and survival.
METHODS AND MATERIALS:
A
total of 1240 cases of EOC treated between 1995 and 2014 were reviewed
to identify CNS metastasis. Demographics, treatment, family history,
genetic testing, and survival outcomes were recorded. Women were then
classified as HBOC+ or HBOC- based on histories and genetic testing
results....
RESULTS:
Of
1240 cases, 32 cases of EOC with CNS metastasis were identified
(2.58%). Median age was 52 years, and 87% had stage III to IV disease. Among those
with documented personal and family history, 66.7% (20/30) were
suspicious for HBOC syndrome. Among those who underwent germline
testing, 71.43% (5/7) had a pathogenic BRCA mutation. The median time
from diagnosis to CNS metastasis was 29 months. At
a median survival of 5.97 months from the time of
CNS metastasis and 43 months from the time of
EOC diagnosis, 29 women died of disease. Univariate Cox proportional
hazard models were used to compare HBOC- to HBOC+ women and did not
reveal a significant difference for survival outcomes.
CONCLUSIONS:
Confirmed
BRCA mutations and histories concerning for HBOC syndrome are common in
women with EOC metastatic to the CNS. We did not demonstrate a
relationship between HBOC status and survival outcomes, but were not
powered to do so.
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