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Blogger's Note: edited index for ovarian cancer related items
Index (subscriber based)
Highlights from the Society of Gynecologic Oncology 2015 Annual Meeting on Women's Cancer
- Pages 3-6
- Not entitled to full text
Summary of the 2015 American Association for Cancer Research (AACR) Annual Meeting
- Pages 7-10
- Not entitled to full text
A phase 2 study of cediranib in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: A trial of the Princess Margaret, Chicago and California Phase II Consortia
Original Research Article- Pages 55-61
Highlights
- •
- Cediranib has activity in recurrent ovarian cancer.
- •
- Expected toxicities were manageable with a dose reduction of cediranib (30 mg daily).
- Not entitled to full text
Risk stratification and outcomes of women undergoing surgery for ovarian cancer
Original Research Article- Pages 62-69
Highlights
- •
- Surgery for ovarian cancer is associated with substantial morbidity.
- •
- Performance of extended cytoreductive procedures is the strongest risk factor for complications.
- •
- Alternative treatment strategies may be considered in women with ovarian cancer at high risk for complications.
- Not entitled to full text
Development of a prediction model for residual disease in newly diagnosed advanced ovarian cancer
Original Research Article- Pages 70-77
Highlights
- •
- Preoperative factors may predict cytoreduction for advanced ovarian cancer.
- •
- Age, ECOG status, CT findings may predict complete or suboptimal cytoreduction.
- Not entitled to full text
Long-term safety of fertility sparing surgery in early stage ovarian cancer: Comparison to standard radical surgical procedures
Original Research Article- Pages 78-82
Highlights
- •
- Conservative treatment of early stage ovarian cancer does not impact on survival outcomes.
- •
- High-risk ovarian cancer patients undergoing conservative surgery experience similar outcomes than those undergoing non-conservative approach.
- Not entitled to full text
Adherence patterns to National Comprehensive Cancer Network (NCCN) guidelines for referral to cancer genetic professionals
Original Research Article- Pages 109-114
Highlights
- •
- Genetic counseling and testing is being underutilized.
- •
- Breast cancer patients are more likely to be referred for genetic counseling.
- •
- Referred patients are likely to follow up with counseling and testing.
- Not entitled to full text
Geographic access to gynecologic cancer care in the United States
Original Research Article- Pages 115-120
Highlights
- •
- A total of 36% of US counties are > 50 miles from the closest gynecologic oncologist.
- •
- A total of 14.8 million women live in these low access counties.
- •
- Outreach is needed to ensure these women have access to gynecologic cancer care.
- Not entitled to full text
Socioeconomic status as a predictor of adherence to treatment guidelines for early-stage ovarian cancer
Original Research Article- Pages 121-127
Highlights
- •
- Disadvantaged populations experience substandard ovarian cancer care.
- •
- Specifically, lower socioeconomic status is an independent predictor of receiving sub-optimal ovarian cancer treatment that deviates from the NCCN guidelines.
- •
- Adherence to the NCCN guidelines has the potential to improve ovarian cancer survival rates among all populations of women.
- Not entitled to full text
The effect of weight-based chemotherapy dosing in a cohort of gynecologic oncology patients
Original Research Article- Pages 154-158
Highlights
- •
- No serous effects were noted in obese patients who received full weight- based dosing
- •
- Heme toxicities were not seen in obese patients with capped vs weight-based dosing
- •
- Weight-based dosing in gynecologic oncology patients appears to be well tolerated
- Not entitled to full text
TP53 hot spot mutations in ovarian cancer: Selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas
Original Research Article- Pages 159-164
Highlights
- •
- Mutant TP53 ovarian cancer cells show selective microtubule stabilizer resistance.
- •
- R248 mutant ovarian cancer cells have reduced epothilone B induced cell death.
- •
- Patients with different TP53 mutations may have different overall survival.
- Not entitled to full text
Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays for preclinical drug sensitivity assays
Original Research Article- Pages 181-189
Highlights
- •
- We describe stable incorporation of low cell numbers into ovarian cancer spheroids.
- •
- Spheroids have uniform geometry and three-dimensional presence.
- •
- Spheroids contain viable cells that can be utilized for high throughput drug screens.
- •
- Spheroids are chemoresistant to cisplatin compared to conventional monolayer cultures.
- •
- Spheroids generated on hanging drop platforms are high throughput amenable.
- Not entitled to full text
The vaginal and gastrointestinal microbiomes in gynecologic cancers: A review of applications in etiology, symptoms and treatment
Review Article- Pages 190-200
Highlights
- •
- Dysbiotic gut and vaginal microbiota may be implicated in carcinogenesis, therapy-related side effects and treatment outcomes in gynecologic cancers.
- •
- Changes in the microbiome following chemotherapy and radiation may impact patient quality of life and/or treatment outcomes.
- •
- Further research is needed to determine optimal composition, function and efficacy of probiotics in reinstating mucosal homeostasis and barrier function.
- Not entitled to full text
Impact of obesity on chemotherapy management and outcomes in women with gynecologic malignancies
Review Article- Pages 201-206
Highlights
- •
- Obesity is associated with an increased risk of developing cancer and worse outcomes.
- •
- Up to 40% of obese patients receive inappropriate low doses of chemotherapy.
- •
- Full dose chemotherapy in obese patients does not lead to increased toxicities.
- •
- Guidelines exist that outline appropriate chemotherapy dosing in obese patients.
- Not entitled to full text
Seeing is saving: The benefit of 3D imaging in gynecologic brachytherapy
Review Article- Pages 207-215
Highlights
- •
- Gynecologic brachytherapy utilizing 3D imaging improves outcomes.
- •
- Clinical atlas based contouring is recommended.
- Not entitled to full text
The impact of pleural disease on the management of advanced ovarian cancer
Review Article- Pages 216-220
Highlights
- •
- Malignant pleural effusion is the most common site of stage IV EOC.
- •
- PET/CT is able to identify stage IV EOC patients.
- •
- VATS can alter the therapeutic management.
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