Osteoporosis Risk and Management in BRCA 1/ 2 carriers who undergo Risk-Reducing Salpingo-oophorectomy

abstract

Highlights:

• •Only 44% of BRCA carriers had a DXA scan after risk-reducing salpingo-oophorectomy, at median of 41 months from testing
• •68% of DXA scans in BRCA carriers who had undergone risk-reducing salpingo-oophorectomy were abnormal
• •There was a 4% rate of a traumatic fracture in BRCA carriers following RRSO

Conclusions

 Women with BRCA mutations who undergo RRSO have many risk factors for bone loss. The majority of these women are not being screened for bone loss. A clear guideline for screening needs to be established to improve detection of post-RRSO bone disease.