(repost) Risk Algorithm Using Serial Biomarker Measurements Doubles # of Screen-Detected Ovarian Cancers...

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Risk Algorithm Using Serial Biomarker Measurements Doubles the Number of Screen-Detected Cancers Compared With a Single-Threshold Rule in the United Kingdom Collaborative Trial of Ovarian Cancer Screening 

 ..... Although HE4 does not improve CA-125 lead time,^22,23 it could help confirm ovarian cancer risk and reduce time to surgery. In the presence of an increasing CA-125, HE4 was increased in samples from 27 of 39 women with ovarian cancer in the PLCO trial.²¹ TVS does not seem to have the resolution to detect iEOC at low CA-125 levels. Twenty-nine (41%) of 70 women with iEOCs in subgroup A had no abnormality on the initial level II scan, and TVS was abnormal in only 17 of the 39 women in the study by Urban et al.²¹ The potential of newer technology^....

 In conclusion, our data support use of velocity-based algorithms as opposed to a predefined single-threshold rule in cancer screening strategies that use blood biomarkers.