Standard chemotherapy with/without bevacizumab for women with newly diagnosed ovarian cancer (ICON7).....

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 Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial
 

Background

The ICON7 trial previously reported improved progression-free survival in women with ovarian cancer with the addition of bevacizumab to standard chemotherapy, with the greatest effect in patients at high risk of disease progression. We report the final overall survival results of the trial.

 Panel

Research in context

Evidence before this study

The primary progression-free survival analysis of the ICON7 trial reported significantly improved progression-free survival when bevacizumab was added to standard chemotherapy in newly diagnosed ovarian cancer. The effect was greatest in patients at high risk of disease progression. Similar progression-free survival findings were reported in the GOG-218 trial.

Added value of this study

In a planned mature analysis of overall survival, no difference in overall survival was noted between those patients who received bevacizumab plus chemotherapy and those who received chemotherapy alone. However, in subgroup analyses, improved overall survival was noted in patients at high risk of disease progression who received bevacizumab compared with those who did not.

Implications of all the available evidence

Bevacizumab may have a role in the treatment of patients with poor-prognosis ovarian cancer. Future work should address questions of treatment duration, targeting, timing, re-challenge, and dose fractionation.