Editorial: The Yin and Yang of Germline TP53 Mutations in Li-Fraumeni Syndrome

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"Remarkably, 18 mutation carriers (4%) developed a cancer during the first year of life."

 Li Fraumeni syndrome (LFS) is one of the most well-recognized cancer predisposition syndromes and serves as a paradigm for the study of heritable susceptibility to cancer. LFS was first reported in 1969 by Li and Fraumeni on the basis of the identification of four families characterized by the autosomal dominant transmission of early-onset tumors.^1,2.....

 Reference to: Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers

JCO Jul 20, 2015:2345-2352; published online on May 26, 2015; 10.1200/JCO.2014.59.5728.

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