|
|
|
|
|
|
|
|
Abstract
Background:
Observational
studies have reported a modest association between obesity and risk of
ovarian cancer; however, whether it is also associated with survival and
whether this association varies for the different histologic subtypes
are not clear. We undertook an international collaborative analysis to
assess the association between body mass index (BMI), assessed shortly
before diagnosis, progression-free survival (PFS), ovarian
cancer-specific survival and overall survival (OS) among women with
invasive ovarian cancer.
Methods:
We used original data from 21 studies, which included 12 390
women with ovarian carcinoma. We combined study-specific adjusted
hazard ratios (HRs) using random-effects models to estimate pooled HRs
(pHR). We further explored associations by histologic subtype.
Results:
Overall, 6715 (54%)
deaths occurred during follow-up. A significant OS disadvantage was
observed for women who were obese (BMI: 30–34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99–1.23); BMI: 35, pHR: 1.12 (95%
CI: 1.01–1.25)). Results were similar for PFS and ovarian
cancer-specific survival. In analyses stratified by histologic subtype,
associations were strongest for women with low-grade serous (pHR: 1.12
per 5 kg m−2) and endometrioid subtypes (pHR: 1.08 per 5 kg m−2), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m−2) subtype, but only the association with high-grade serous cancers was significant.
Conclusions:
Higher BMI is associated with adverse survival among the majority of women with ovarian cancer.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.