Pan-Cancer Genetic Testing Provides Important Info for Identifying/Treating At-Risk Populations (re: NCCN)

Targeted Oncology

....Pan-cancer multigene panels include genes that are expressed across a variety of cancer types, and offer the possibility of identifying potentially deleterious genes in patients who might not otherwise be tested.3,4 For example, an individual with a family history of breast cancer (who would qualify for genetic testing for BRCA1/BRCA2 mutation) might also have a mutation in one or more of the LS genes, which would generally not be evaluated......(eg. NCCN guidelines)

 FIGURE. Examples of LS-mutation–positive patients who do not meet NCCN LS testing criteria.3

FIGURE. Examples of LS-mutation–positive patients who do not meet NCCN LS testing criteria.3 - See more at: http://www.targetedonc.com/publications/targeted-therapy-news/2015/may-2015/pan-cancer-genetic-testing-provides-important-information-for-identifying-and-treating-at-risk-populations#sthash.AmxIpdif.dpuf

Pan-cancer multigene panels include genes that are expressed across a variety of cancer types, and offer the possibility of identifying potentially deleterious genes in patients who might not otherwise be tested.^3,4 For example, an individual with a family history of breast cancer (who would qualify for genetic testing for BRCA1/BRCA2 mutation) might also have a mutation in one or more of the LS genes, which would generally not be evaluated.  - See more at: http://www.targetedonc.com/publications/targeted-therapy-news/2015/may-2015/pan-cancer-genetic-testing-provides-important-information-for-identifying-and-treating-at-risk-populations#sthash.AmxIpdif.dpuf