PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation (sugar)

Nature - open access  (highly technical)


plain english link -  Starving cancer cells of sugar could be the key to future treatment


also: Warburg Effect as referenced in Nature publication (Wiki)

Warburg effect

From Wikipedia, the free encyclopedia

The phrase "Warburg effect" (/ˈvɑrbʊərɡ/) is used for two unrelated observations in biochemistry, one in plant physiology and the other in oncology, both due to Nobel laureate Otto Heinrich Warburg.

Contents

• 1 Plant physiology
• 2 Oncology
  • 2.1 Basis
  • 2.2 Possible explanations of the effect
  • 2.3 Glycolytic inhibitors
• 3 Alternative models
• 4 Cancer metabolism and epigenetics
• 5 References