Analyze Association of BRCA2 Arg372His Polymorphism With Ovarian Cancer Risk

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Objective: Studies investigating the association between BRCA2 Arg372His polymorphism and ovarian cancer risks have yielded conflicting results.

Methods: We carried out a meta-analysis of 8488 ovarian cancer cases and 14,510 controls from 7 case-control studies in 5 articles published. The association between BRCA2 Arg372His polymorphism and ovarian cancer susceptibility was calculated using pooled odds ratios (ORs) appropriately derived from fixed effects models.

Results: There were no significant associations between BRCA2 Arg372His polymorphisms and ovarian cancer risk in overall comparisons in all genetic models .....

Conclusions: This meta-analysis indicates that the BRCA2 Arg372His polymorphism is not associated with ovarian cancer risk for whites. Asian and African populations should be further studied.

Ovarian cancer is the deadliest cancer of the female reproductive system, with over 21,980 new cases and over 14,270 deaths in the United States in 2014.¹ In most of the carcinomas, ovarian cancer is a multifactorial disease, and hormonal factors, environment and genetic factors all play significant roles in its development.^2–4 The genetic basis of ovarian cancers has been investigated in many studies. BRCA1, BRCA2, SMAD6, RAD51C, RAD51D, LIN28B, CASP8, MLH1, MSH2, RB1, and MTDH have all been implicated.^5–13 Recently, 3 genomewide association studies found several common susceptibility alleles in 4 loci to be strongly associated with ovarian cancer risk.^3,14–16 Examination of genetic polymorphisms may explain individual differences in cancer risk.^17......