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open access
ABSTRACT
Databases
pertaining to various diseases provide valuable resources on particular
genes of interest but lack the molecular subtype and
epithelial-mesenchymal transition status. CSIOVDB is a transcriptomic
microarray database of 3,431 human ovarian cancers, including carcinoma
of the ovary, fallopian tube, and peritoneum, and metastasis to the
ovary. The database also comprises stroma and ovarian surface epithelium
from normal ovary tissue, as well as over 400 early-stage ovarian
cancers. This unique database presents the molecular subtype and
epithelial-mesenchymal transition status for each ovarian cancer sample,
with major ovarian cancer histologies (clear cell, endometrioid,
mucinous, low-grade serous, serous) represented. Clinico-pathological
parameters available include tumor grade, surgical debulking status,
clinical response and age. The database has 1,868 and 1,516 samples with
information pertaining to overall and disease-free survival rates,
respectively. The database also provides integration with the copy
number, DNA methylation and mutation data from TCGA. CSIOVDB seeks to
provide a resource for biomarker and therapeutic target exploration for
ovarian cancer research.
Querying a gene of interest
CSIOVDB seeks to provide users with the expression
profiles of certain genes of interest relevant to ovarian cancer; in
particular, the molecular subtype distribution and subtype-specific
outcomes in terms of overall survival and disease-free (progression- and
recurrence-free) survival......
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