abstract
AIMS:
The
distinction between
primary ovarian mucinous tumors and appendiceal
mucinous neoplasms metastatic to the ovary can be challenging given the
overlap of morphologic features and immunohistochemical expression of
traditional markers. SATB2 has been recently described as a sensitive
and specific marker of colorectal epithelium. Its expression in
appendiceal mucinous tumors and its role in their distinction from
ovarian neoplasms have not been fully characterized.
CONCLUSIONS:
SATB2 is frequently expressed in appendiceal mucinous neoplasms. In the
context of a mucinous neoplasm involving the ovary, any SATB2 positivity
should raise the possibility of appendiceal origin. Expression of CK20,
CDX2 and MUC2 supports appendiceal origin only when diffuse and strong.
These and other markers such as CK7 and PAX8 are recommended in the
work-up of ovarian mucinous tumors with any clinical or pathologic
features suspicious for secondary origin.
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