|
|
|
|
|
|
|
|
abstract
Highlights
- •The interaction between smoking and chemotherapy on survival from ovarian cancer is unknown.
- •Smoking reduced overall and progression-free survival among patients with mucinous ovarian cancer receiving adjuvant chemotherapy.
- •Smoking reduced progression-free survival among all ovarian cancer patients receiving neoadjuvant chemotherapy.
Abstract
Objective
Tobacco smoking by cancer patients is associated with increased mortality. Less is known of the impact of smoking on recurrence risk and interaction with chemotherapy treatment. We examined these associations in ovarian cancer.Methods
Patients were identified from the Alberta Cancer Registry between 1978 and 2010 and were oversampled for less-common histologic ovarian tumor types. Medical records were abstracted for 678 eligible patients on lifestyle, medical and cancer treatment, and review of pathology slides was performed for 605 patients. We estimated hazard ratios (HR) and 95% confidence intervals (CI) using Cox proportional hazard models adjusted for age at diagnosis, race, stage and residual disease.Results
Among patients receiving adjuvant chemotherapy (N = 432), current smoking was significantly associated with shorter duration of overall (OS; HR, 8.56; 95% CI, 1.50–48.7) and progression-free (PFS; HR, 5.74; 95% CI, 1.05–31.4) survival from mucinous ovarian cancer only. There was no significant association between neoadjuvant chemotherapy and survival. However,among patients receiving neoadjuvant chemotherapy (N = 44), current smokers had shorter PFS (HR, 4.32; 95% CI, 1.36–13.8; N = 32 progressed/9 censored events) compared to never smokers, but the HRs were not statistically different across smoking categories (P interaction = 0.87).
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.