abstract
BACKGROUND:
The
coexistence primary cancers of the endometrium and ovary are relatively
uncommon. The purpose of this study was to characterize patients
diagnosed primary synchronous endometrial and ovarian cancer (SEOC),
endometrial cancer (EC) with ovarian metastasis, and ovarian cancer (OC)
with endometrial metastasis and compare clinicopathologic variables and
prognosis.
MATERIALS AND METHODS:
All
the patients with diagnosis of both endometrium and OC, who
hospitalized between 2002 and 2012 in an academic center affiliated to
Tehran University of Medical Sciences, were evaluated with respect to
different clinicopathologic variables, follow-up times, and outcomes.
RESULTS:
Fifty-five
patients had been diagnosed with both endometrium and OC. 17, 26, and
12 patients were diagnosed as SEOC, EC, and OC, respectively. The
frequency of abnormal uterine bleeding was significantly lower in OC
(16.7%) compared to others (58.8% in SEOC and 53.8% in EC). However, the
abdominal/pelvic pain was significantly higher in OC (50%) compared to
others (35.3% in SEOC and 34.6% in EC) (P < 0.05). Complex atypical
hyperplasia (87.5%), endometriosis (88.8%), and endometrioid carcinoma
(54.5%) was observed most in SEOC group. The duration of follow-up time
was between 3 and 171 months with a mean of 16 months. There was no
death in SEOC who followed. Survivals of patients between three group
were statistically significant (P = 0.032).
CONCLUSION:
Our
results showed that overall survival (OS) and progression-free survival
(PFS) of SEOC patients is better than those with EC and OC (P = 0.032).
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