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JAMA Network
Importance Carcinoma of unknown primary (CUP) accounts for 3% to 5% of all cancers and is associated with poor prognosis. Familial clustering of different cancer sites with CUP is unknown and may provide information regarding etiology, as well as elevated cancer risks in relatives.
Objective To quantify the risk of cancer by site in first- and second-degree relatives and first cousins of individuals with CUP......
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