We sequenced germline DNA from forty-seven women diagnosed with OC at
age 40 or younger ascertained through a gynecologic oncology tissue bank
or referred from outside providers using BROCA
Highlights
•Women with ovarian carcinoma age ≤40 have a high rate of BRCA1 mutations.
•Deleterious germline mutations were also identified in BRCA2, MSH2, and RAD51D.
•The family history did not predict mutation status in these young patients.
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