Genetic characterization of early onset ovarian carcinoma - Gynecologic Oncology

abstract

 We sequenced germline DNA from forty-seven women diagnosed with OC at age 40 or younger ascertained through a gynecologic oncology tissue bank or referred from outside providers using BROCA

 Highlights

• •Women with ovarian carcinoma age ≤40 have a high rate of BRCA1 mutations.
• •Deleterious germline mutations were also identified in BRCA2, MSH2, and RAD51D.
• •The family history did not predict mutation status in these young patients.