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abstract
Background: The evidence on the relation of family history of cancers other than breast cancer to breast cancer risk is conflicting,
and most studies have not assessed specific breast cancer subtypes.
Methods: We assessed the relation of first-degree family history of breast, prostate, lung, colorectal, ovarian, and cervical cancer
and lymphoma or leukemia, to the risk of estrogen receptor–positive (ER+), ER−,
and triple-negative breast cancer in data from the African American
Breast Cancer Epidemiology and Risk Consortium...
Results: There were 3,023 ER+ and 1,497 ER− breast cancer cases (including 696 triple-negative cases) and 17,420 controls. First-degree family history of breast cancer
was associated with increased risk of each subtype: OR = 1.76 (95% CI, 1.57–1.97) for ER+, 1.67 (1.42–1.95) for ER−, and 1.72 (1.38–2.13) for triple-negative breast cancer. Family history of cervical cancer was associated with increased
risk of ER− (OR = 2.39; 95% CI, 1.36–4.20), but not ER+ cancer. Family history of both breast and prostate cancer was associated with increased risk of ER+ (3.40; 2.42–4.79) and ER− (2.09; 1.21–3.63) cancer, but family history of both breast and lung cancer was associated only with ER− cancer (2.11; 1.29–3.46).
Conclusions: A family history of cancers other than breast may influence the risk of breast cancer, and associations may differ by subtype.
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