HE4, CA125 and risk of ovarian malignancy algorithm (ROMA) as diagnostic tools for ovarian cancer in patients with a pelvic mass

abstract

 HE4, CA125 and risk of ovarian malignancy algorithm (ROMA) as diagnostic tools for ovarian cancer in patients with a pelvic mass: An Italian multicenter study

Highlights

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Multicenter study with prospective and consecutive enrollment evaluating CA125, HE4 and ROMA in patients with pelvic mass undergoing surgery.

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ROMA presented well balanced diagnostic performance, with higher SN than HE4 and higher SP than CA125.

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HE4 seems to be more efficient than CA125 in ruling in EOC patients in the disease group.