Inflammation as a cause of Venous Thromboembolism - Critical Reviews in Oncology / Hematology

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Article Outline

1. 1. Introduction
2. 2. Genetic Investigations
   1. 2.1. Genetic Association Studies
   2. 2.2. Gene-Targeted Animal Studies
3. 3. Inflammation-Related Medical Conditions Or Diseases Associated With Venous Thromboembolism
   1. 3.1. Trauma and Venous Thromboembolism
   2. 3.2. Cancer and Venous Thromboembolism
4. 4. Heart Diseases and Venous Thromboembolism
5. 5. Chronic Obstructive Pulmonary Disease and Venous Thromboembolism
   1. 5.1. Pregnancy and Venous Thromboembolism
   2. 5.2. Surgery and Venous Thromboembolism
   3. 5.3. Diabetes and Venous Thromboembolism
   4. 5.4. Aging and Venous Thromboembolism
6. 6. Hormone Replacement Therapy and Venous Thromboembolism
   1. 6.1. Infections and Venous Thromboembolism
   2. 6.2. Obesity and Venous thromboembolism
   3. 6.3. Superficial Venous Thrombosis and Venous Thromboembolism
   4. 6.4. Autoimmune Diseases and Venous Thromboembolism
7. 7. Conclusions
8. Author contributions
9. Conflicts of interest
10. References
11. Biography

Highlights

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  Genetic association studies have established the fundamental role of genetic background in predisposition to venous thromboembolism (VTE) and variable inflammatory processes in individuals.
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  Several inflammation-related conditions, especially autoimmune diseases, malignancies, infectious diseases, metabolic diseases, and trauma have been associated with an increased risk of VTE.
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  Future studies with larger sample sizes are required to address whether the properties of the inflammatory process, particularly intensity and duration, are useful in determining the risk of VTE and following outcomes.