Outcome of genetic evaluation of patients with kidney cancer referred for suspected hereditary cancer syndromes

abstract

Highlights

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  We identified several factors that may predict positive test results in patients with kidney cancer undergoing evaluation in a clinical genetics clinic. Although these risk factors have previously been associated with cancer syndromes, a need for studies of testing practices remains.
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  Our data suggest that in patients with kidney cancer evaluated for hereditary cancer syndromes, young age is associated with diagnosis of RCC syndromes, whereas syndromic manifestations and multiple primaries are found in Lynch syndrome.
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  These results, along with clinical pathway, suggested for evaluating patients with kidney cancer for inherited cancer syndrome may be useful for practicing urologists to select patients with kidney cancer to refer for genetic counseling.