Association and prognostic significance of BRCA1/2-mutation status....PD-1/PD-L1 Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, February 13, 2016

Association and prognostic significance of BRCA1/2-mutation status....PD-1/PD-L1



Abstract

Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer

 These findings support a link between BRCA1/2-mutation status, immunogenicity and survival, and suggesting that BRCA1/2-mutated HGSOCs may be more sensitive to PD-1/PD-L1 inhibitors compared to HR-proficient HGSOCs.

 

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