abstract
define: IFRT + delivering radiation to only those areas of the body involved
OBJECTIVES:
This
study aimed to report on long-term effectiveness of
involved field
radiation therapy (IFRT) in the salvage of localized recurrent
ovarian cancer (ROC).
METHODS:
A retrospective analysis of
27 patients with a diagnosis of epithelial
ovarian cancer
who received tumor volume-directed IFRT for localized extraperitoneal
recurrences (either as consolidation after cytoreductive surgery (CRS)
or as attempted salvage if unresectable) forms the basis of this report.
All patients were heavily pretreated with multiple chemotherapy
regimens. Involved field radiation therapy was primarily with external
beam (median dose, 50.4 Gy). Local recurrence-free survival (LRFS) was
defined as freedom from in-field recurrences and was considered as a
measure of effectiveness of radiotherapy.
Statistical analyses evaluated
association between disease-free survival, overall survival, LRFS, and
various prognostic factors. Comparison was also made with a similar but
unmatched cohort with localized recurrences salvaged by additional
chemotherapy instead of local therapies (NIFRT group).
RESULTS:
Of
27 patients, 17 had optimal CRS before RT. The actuarial survival at 5
and 10 years (in parenthesis) from date of radiation were LRFS (70% and
60%), overall survival (30% and 19%), and disease-free survival (33% and
20%). None of the NIFRT patients survived beyond 5 years from
initiation of salvage chemotherapy.
CONCLUSIONS:
Long-term
follow-up in this selected series confirmed the benefit of IFRT (±CRS)
in localized ROC. Chemotherapy salvage in a similar NIFRT group was not
equivalent, suggesting a role for locoregional therapies in selected
patients with ROC.
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