NCI-MATCH: A Status Report and Future Directions Feb 1st

NCI

We will also be opening 12 to 14 additional treatment arms, with the expectation of having as many as 22 to 24 arms open by May 2016.

....Because our experience to date is leading to some modifications in the trial, the pause in enrollment to the screening step is expected to continue until all of these changes are implemented. We expect to resume enrollment of new patients by May 2016.

The ongoing interim analysis, results from which will be publicly presented in early spring, will include data on:

• the diversity of cancer types (common and rare) among patients who have enrolled in the trial
• patients with a mutation that matches to one of the 10 available treatments versus those with no match
• the estimated proportion of patients who may have a mutation that matches to one of the 22 to 24 treatment arms, once all arms become available
• the type and quality of tumor samples submitted by the institutions enrolling patients in the trial
• the performance and turnaround time of the four laboratories supporting the trial with sample processing and genomic testing

The interim analysis will provide a snapshot of how this ambitious trial unfolded and will help the trial leadership make necessary refinements. Already we are making important changes to NCI-MATCH....