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abstract
Objective
A small percentage of
pediatric solid cancers arise as a result of clearly identified
inherited predisposition syndromes and nongenetic lesions. Evidence
supports pre-emptive surgery for children with genetic [multiple
endocrine neoplasia type 2 (MEN2), familial adenomatous polyposis
syndrome (FAP), hereditary nonpolyposis colorectal cancer (HNPCC), and
hereditary diffuse gastric cancer (HDGC) and nongenetic [thyroglossal
duct cysts (TGDC), congenital pulmonary airway malformations (CPAM),
alimentary tract duplication cysts (ATDC), and congenital choledochal
cysts (CCC)] developmental anomalies. Our aim was to explore the utility
of risk reduction surgery to treat and prevent cancer in children........
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