BRCA testing, treatment patterns and survival in platinum-sensitive recurrent ovarian cancer – an observational cohort study

open access

 Owing to the enhanced susceptibility of platinum-containing agents in BRCAm platinum-sensitive recurrent ovarian cancer and the prevalence of BRCAm in recurrent disease, it is important to evaluate BRCA testing, treatment patterns and survival in patients who may benefit most from platinum therapy. The purpose of this study was to assess BRCA testing patterns, treatment patterns, and survival in patients with platinum-sensitive recurrent ovarian cancer.

 

Conclusion

This study demonstrates in an academic oncology center with extensive genetic services support that BRCA testing rates increased during the study period and that the likelihood of BRCA testing increased with lower age, positive family history, and presenting time. However, wider BRCA testing may have identified additional BRCA carriers. Patients tested for BRCAm had greater median overall survival rates versus untested patients and a corresponding greater number of systemic treatment lines. BRCAwt patients had similar outcomes to BRCAm patients. Overall, this study continues to demonstrate the distinct clinical behavior of BRCA-mutated ovarian cancer and underscores the importance of appropriate genetic risk assessment and BRCA testing.

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