Frozen Section Helps Diagnose Early Ovarian Cancer (Cochrane/Reuters/Medscape) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Monday, March 21, 2016

Frozen Section Helps Diagnose Early Ovarian Cancer (Cochrane/Reuters/Medscape)

(Medscape) Reuters Health
 March 20, 2016:
NEW YORK (Reuters Health) - Intraoperative frozen section analysis can help distinguish early ovarian cancer from a benign mass, though it is less accurate for borderline tumors, according to a Cochrane review.
Dr. Nithya D.G. Ratnavelu, from Northern Gynaecological Oncology Centre, Gateshead, UK, and colleagues used data from 38 studies to assess the accuracy of frozen section for diagnosing suspicious pelvic masses. Overall, 3200 women had invasive cancer, 1055 had borderline tumors and 6926 had benign tumors, as determined by paraffin section. The cohort included 3953 participants with a frozen section result of either borderline or invasive cancer.
"Studies with small numbers of disease-negative cases (borderline cases) had more variation in estimates of specificity," the authors wrote in the Cochrane Database of Systematic Reviews.
A frozen section diagnosis of benign mass would be right 94% of the time, and a frozen section diagnosis of malignancy would be right 99% of the time, according to the March 1 report.
In contrast, a frozen section diagnosis of borderline tumor would turn out to be cancer only 21% of the time.....
Diagnostic Test Accuracy Review

Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses


To assess the diagnostic test accuracy of frozen section (index test) to diagnose histopathological ovarian cancer in women with suspicious pelvic masses as verified by paraffin section (reference standard).....


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