abstract
PURPOSE:
The
aim of the study was to determine if
increasing post-therapy
calcification in peritoneal metastases in
recurrent low-grade serous
ovarian carcinomas indicated response to therapy.
MATERIALS AND METHODS:
Retrospective
analysis of patients with histologically confirmed, recurrent low-grade
serous ovarian carcinoma who received treatment at our institution
between 2000 and 2014 was performed. Only patients who had calcified
tumor implants and showed either interval increase or decrease in tumor
calcification following therapy were included in the study. Pre- and
post-therapy CT scans of these patients were reviewed by 2 radiologists
independently.
Changes in the tumor calcification status and tumor
deposits size were correlated with serum CA-125 levels. Fisher's exact
test was used to assess the association between peritoneal deposit and
calcification status with serum CA-125 status.
RESULTS:
35
Patients were included in the study. Based on serial serum CA 125
levels, 22 patients (63%) had progressive disease, 12 (34%) had partial
response and 1 (3%) had stable disease. Using RECIST 1.1, 16 had
progressive disease, 3 had partial response and 16 had stable disease.
In the patients with progressive disease, post-therapy tumor
calcification increased in 77% and decreased in 23%. Fischer's exact
test showed that serum CA 125 change was significantly associated with
change in size of peritoneal deposits and calcification change.
CONCLUSIONS:
This
preliminary study shows that post-therapy increase in peritoneal
implant calcification in low-grade serous ovarian carcinomas is not an
indicator of response to therapy.
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