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abstract
Highlights
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- Cancers evolve mechanisms for evading and suppressing the immune system
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- A number of different immunotherapy approaches have been used and show promise in gynecologic cancers
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- Emerging data reveal durable responses in some patients with gynecologic cancers
Abstract
During
the past decade significant progress in the understanding of
stimulatory and inhibitory signaling pathways in immune cells has
reinvigorated the field of immuno-oncology. In this review we outline
the current immunotherapy based approaches for the treatment of
gynecological cancers, and focus on the emerging clinical data on immune
checkpoint inhibitors, adoptive cell therapies, and vaccines. It is
anticipated that in the coming years biomarker-guided clinical trials,
will provide for a better understanding of the mechanisms of response
and resistance to immunotherapy, and guide combination treatment
strategies that will extend the benefit from immunotherapy to patients
with gynecologic cancers.
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