Mar 4, 2016: Genetics of Breast and Gynecologic Cancers

Health Professional Version - NCI

Sections

• Executive Summary
• Introduction
• Penetrance of Inherited Susceptibility to Hereditary Breast and/​or Gynecologic Cancers
• High-Penetrance Breast and/​or Gynecologic Cancer Susceptibility Genes
• Moderate-Penetrance Genes Associated With Breast and/​or Gynecologic Cancer
• Low-Penetrance Genes and Loci
• Clinical Management of BRCA Mutation Carriers
• Clinical Management of Other Hereditary Breast and/​or Gynecologic Cancer Syndromes
• Psychosocial Issues in Inherited Breast and Ovarian Cancer Syndromes
• Changes to This Summary (03/​04/​2016)
• About This PDQ Summary
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Changes to This Summary (03/04/2016)

 eg.:

The Li-Fraumeni syndrome section was comprehensively reviewed and extensively revised.

Revised text to state that an updated set of operational criteria for the diagnosis of Cowden syndrome based on a systematic literature review has been suggested and is currently utilized in the National Comprehensive Cancer Network (NCCN) guidelines.

Added text to state that despite discordant findings regarding RRSO and breast cancer risk in the existing literature, aggregate data suggest that there is a benefit, although the magnitude of this benefit may not be fully understood. Further prospective studies are needed to confirm these findings.