Ovarian cancer in Lynch syndrome; a systematic review (March 2016) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Monday, March 14, 2016

Ovarian cancer in Lynch syndrome; a systematic review (March 2016)



abstract
 
March 2016


Highlights

In this systematic review 747 ovarian cancers in women with LS were evaluated.
The mean age of diagnosis of ovarian cancer was 45.3 years (range 19–82 years).
Most common histological types were endometrioid or clear cell carcinomas.
65% of ovarian cancers were early stage (FIGO I/II) with a good overall survival.
In six studies, 7/22 (32%) ovarian cancers were found during surveillance.

Abstract

Objective

The aim was to systematically review the characteristics of ovarian cancer in women with Lynch syndrome (LS) and evaluate the role of surveillance in detection of ovarian cancer in LS.

Methods

All studies between 1979 and 2015 of women with ovarian cancer and LS or at 50% risk of LS were evaluated. Two reviewers independently evaluated eligible studies and extracted data on age at diagnosis, histological type, FIGO stage, and way of detection according to pre-specified criteria. The studies were assessed for quality using the Newcastle-Ottawa quality assessment scales.

Results

The quality score of the 49 identified studies was at least 6 out of 8 and provide clinical information on 747 LS women with ovarian cancer. The mean age at diagnosis was 45.3 (range 19–82) years. Most frequent mutations were MSH2 (47%) and MLH1 (38%). Histopathological data were available for 445 women. The most frequently reported histological type was mixed type (mucinous/endometrioid/clear cell carcinomas) (n = 136; 31%). Most tumours (281, 65%) were diagnosed at an early stage (FIGO I/II). Six studies evaluating the effect of surveillance of ovarian cancer, reported that seven of 22 (32%) ovarian cancers were found during surveillance, 6/7 (86%) were detected at an early stage.

Conclusion

This systematic review describes that ovarian cancer in women with LS has a wide age-range of onset, is often diagnosed at an early stage with frequently endometrioid/clear cell histology. Data about the role of surveillance in detection of ovarian cancer in women with LS are scarce however detection at an early stage seems possible.

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