Topics in Uterine Pathology: Difficult Diagnoses, New Developments, and Useful Diagnostic Techniques (eg. Lynch syndrome)

Topics in Uterine Pathology: Difficult Diagnoses

This issue of AJSP: Reviews & Reports deals with some vexing issues of endometrial/uterine pathology that can confront the pathologist in a biopsy or curettage specimen, or in a hysterectomy.

Drs. Singh and Ganesan first discuss the issue of endometrioid carcinoma of the endometrium in which clear cells are present. Various explanations for the presence of clear cells are discussed, and a strategy provided for determining the correct diagnosis. Some such cases prove to have a component of clear cell carcinoma, and the authors discuss the significance of this finding. They then turn to the topic of mixed endometrial carcinomas and endometrial carcinomas with ambiguous differentiation. Finally, the authors discuss the association between certain types of endometrial carcinoma, chiefly the endometrioid and clear cell types, and the Lynch syndrome, and how the diagnosis of Lynch syndrome is established.....