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case report: (abstract)
Abdominal wall metastasis following open nephroureterectomy for upper tract urothelial carcinoma in a patient with Lynch syndrome
Summary
A 74-year-old man developed
the rare complication of an abdominal wall metastasis following open
nephroureterectomy for upper
tract urothelial carcinoma (UTUC). This
occurred in the setting of synchronous contralateral ureteric and
metachronous colorectal
carcinomas. Immunohistochemistry
demonstrated loss of the mutS homolog 6 (MSH6) mismatch repair (MMR)
protein in the metastatic
abdominal wall and colonic lesions,
which in conjunction with meeting the Amsterdam II criteria, is strongly
suggestive of
Lynch syndrome (LS). Surgical resection
of the recurrence was performed with clear margins and neither
recurrence nor spread
during short-term follow-up.
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